The differential effect of food intake and β-adrenergic stimulation on adipose-derived hormones and cytokines in man

被引:163
作者
Orban, Z
Remaley, AT
Sampson, M
Trajanoski, Z
Chrousos, GP
机构
[1] NICHHD, Dev Endocrinol Branch, Bethesda, MD 20892 USA
[2] NIH, Dept Clin Pathol, Bethesda, MD 20892 USA
[3] Graz Univ Technol, Inst Biomed Engn, A-8010 Graz, Austria
关键词
D O I
10.1210/jc.84.6.2126
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We determined whether the physiologic changes that accompany food intake or sympathetic activation by beta-adrenergic stimulation result in alterations in the secretion of leptin, tumor necrosis factor-cu (TNF alpha), or interleukin-6 (IL-6) by serially sampling sc abdominal adipose interstitial fluid by open-flow microperfusion before and after a standardized meal and in response to isoproterenol (1 mu mol/L) delivered locally. Post cibum IL-6 rose up to 5-fold, whereas leptin and TNF alpha secretion did not change; TNF alpha, but not IL-6, correlated positively with indices of lipolysis. Isoproterenol-induced lipolysis was accompanied by a transient 40% reduction in leptin and a parallel 85% elevation of TNF alpha concentration, whereas IL-6 levels did not change; again, TNF alpha correlated positively with lipolysis. These data show that secretion of some, but not all, metabolically relevant polypeptides by adipose tissue is modulated within a short time frame by food or stress stimuli, suggesting a role of these peptides in local autocrine/paracrine or distant endocrine effects on fat metabolism TNF alpha's close correlation with lipolysis suggests that this cytokine participates in a local positive autocrine feedback loop, potentiating lipolysis and inhibiting insulin's antilipolytic actions. The regulations of adipose leptin, TNF alpha, and IL-6 secretion seem distinct from each other and different in the fed vs. fasting state.
引用
收藏
页码:2126 / 2133
页数:8
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