Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus

被引:435
作者
Kew, O
Morris-Glasgow, V
Landaverde, M
Burns, C
Shaw, J
Garib, Z
André, J
Blackman, E
Freeman, CJ
Jorba, J
Sutter, R
Tambini, G
Venczel, L
Pedreira, C
Laender, F
Shimizu, H
Yoneyama, T
Miyamura, T
van der Avoort, H
Oberste, MS
Kilpatrick, D
Cochi, S
Pallansch, M
de Quadros, C
机构
[1] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA
[2] Pan Amer Hlth Org, Caribbean Epidemiol Ctr Lab, Port of Spain, Trinidad Tobago
[3] PAHO, Div Vaccines & Immunizat, Washington, DC 20037 USA
[4] Minist Hlth, Santo Domingo, Dominican Rep
[5] Minist Publ Hlth, Port au Prince, Haiti
[6] Ctr Dis Control & Prevent, Vaccine Preventable Dis Eradicat Div, Natl Immunizat Program, Atlanta, GA 30333 USA
[7] PAHO, Santo Domingo, Dominican Rep
[8] PAHO, Port au Prince, Haiti
[9] Natl Inst Infect Dis, Dept Virol 2, Shinjuku Ku, Tokyo 162, Japan
[10] Natl Inst Publ Hlth & Environm, Polio Lab, RIVM, NL-3720 BA Bilthoven, Netherlands
关键词
D O I
10.1126/science.1068284
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very Low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.
引用
收藏
页码:356 / 359
页数:4
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