Genetics of autoimmune diseases in humans and in animal models

被引:45
作者
Morahan, G
Morel, L
机构
[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
[2] Univ Florida, Dept Med, Gainesville, FL 32610 USA
关键词
D O I
10.1016/S0952-7915(02)00401-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent applications of the genetic characterisation of autoimmunity in humans and in animal models have allowed the further mapping of many disease loci and, in some cases, the identification of disease genes. New approaches to the analysis of mapping, characterisation and identification of susceptibility genes have also been developed.
引用
收藏
页码:803 / 811
页数:9
相关论文
共 68 条
[1]   Understanding autoimmune diabetes: insights from mouse models [J].
Adorini, L ;
Gregori, S ;
Harrison, LC .
TRENDS IN MOLECULAR MEDICINE, 2002, 8 (01) :31-38
[2]   Genomewide scans of complex human diseases:: True linkage is hard to find [J].
Altmüller, J ;
Palmer, LJ ;
Fischer, G ;
Scherb, H ;
Wjst, M .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (05) :936-950
[3]   The role of complement in inflammation and adaptive immunity [J].
Barrington, R ;
Zhang, M ;
Fischer, M ;
Carroll, MC .
IMMUNOLOGICAL REVIEWS, 2001, 180 :5-15
[4]   High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis [J].
Barton, A ;
Eyre, S ;
Myerscough, A ;
Brintnell, B ;
Ward, D ;
Ollier, WER ;
Lorentzen, JC ;
Klareskog, L ;
Silman, A ;
John, S .
HUMAN MOLECULAR GENETICS, 2001, 10 (18) :1901-1906
[5]   Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? [J].
Benoist, C ;
Mathis, D .
NATURE IMMUNOLOGY, 2001, 2 (09) :797-801
[6]  
Bergholdt R, 2001, DIABETOLOGIA, V44, pA53
[7]   Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein [J].
Boackle, SA ;
Holers, VM ;
Chen, XJ ;
Szakonyi, G ;
Karp, DR ;
Wakeland, EK ;
Morel, L .
IMMUNITY, 2001, 15 (05) :775-785
[8]   Genetic modifiers of systemic lupus erythematosus in FcγRIIB-/- mice [J].
Bolland, S ;
Yim, YS ;
Tus, K ;
Wakeland, EK ;
Ravetch, JV .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (09) :1167-1174
[9]   An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice [J].
Boulard, O ;
Damotte, D ;
Deruytter, N ;
Fluteau, G ;
Carnaud, C ;
Garchon, HJ .
DIABETES, 2002, 51 (07) :2141-2147
[10]   Transgenic models of autoimmune disease [J].
Boyton, RJ ;
Altmann, DM .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2002, 127 (01) :4-11