Modeling spatial heterogeneity of disease risk and evaluation of the impact of vaccination

被引：14

作者：

Ali, Mohammad ^{[1
]}

Emch, Michael ^{[2
]}

Yunus, Mohammad ^{[3
]}

Clemens, John ^{[1
]}

机构：

[1] Int Vaccine Inst, Kwanak Ku, Seoul 151818, South Korea

[2] Univ N Carolina, Dept Geog, Chapel Hill, NC USA

[3] ICDDR B, Dhaka 1000, Bangladesh

来源：

VACCINE | 2009年 / 27卷 / 28期

基金：

美国国家科学基金会;

关键词：

Spatial analysis; Vaccine; Cholera; ORAL CHOLERA VACCINES; ENDEMIC CHOLERA; FIELD TRIAL; FOLLOW-UP; BANGLADESH; SEASONALITY; EFFICACY; CLIMATE;

D O I：

10.1016/j.vaccine.2009.03.085

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We reanalyzed data from a phase III trial for the killed oral cholera vaccine to test two hypotheses: there will be a greater impact of the vaccine in areas where there is a low force of infection, and the spatial pattern of disease transmission will change after a mass vaccination campaign. Spatial regression was used to test these hypotheses accounting for spatial heterogeneity in disease and vaccine coverage. The results of the analyses confirm both hypotheses. The paper also shows how spatial analysis can be used to understand the impact of vaccination when there are spatially heterogeneous disease distributions. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3724 / 3729

页数：6

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