The role of multiple SOS boxes upstream of the Mycobacterium tuberculosis lexA gene -: identification of a novel DNA-damage-inducible gene

被引：21

作者：

Dullaghan, EM ^{[1
]}

Brooks, PC ^{[1
]}

Davis, EO ^{[1
]}

机构：

[1] Natl Inst Med Res, Div Mycobacterial Res, London NW7 1AA, England

来源：

MICROBIOLOGY-SGM | 2002年 / 148卷

关键词：

LexA; SOS box; mycobacteria;

D O I：

10.1099/00221287-148-11-3609

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Four potential binding sites for LexA were identified upstream of the Mycobacterium tuberculosis lexA gene. A mutational analysis of these sites in a lexA-lacZ reporter construct revealed that only one of these SOS boxes was required for DNA-damage-mediated regulation of lexA expression. A novel DNA-damage-inducible gene, Rv2719c, was identified that was divergently transcribed relative to lexA; the other three SOS boxes were found to be involved in regulating expression of this novel mycobacterial-specific gene. The SOS boxes lay in the respective promoter regions of the genes that they regulated.

引用

页码：3609 / 3615

页数：7

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