Synthesis of silicon analogues of acyclonucleotides incorporable in oligonucleotide solid-phase synthesis

被引：29

作者：

Thibon, J ^{[1
]}

Latxague, L ^{[1
]}

Deleris, G ^{[1
]}

机构：

[1] UNIV BORDEAUX 2,CHIM BIOORGAN LAB,F-33076 BORDEAUX,FRANCE

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 14期

关键词：

D O I：

10.1021/jo962165p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the four silicon analogues of acyclonucleosides was described. In every case, the silicon atom was introduced onto an allyl group on the natural nucleobase following a hydrosilylation reaction. Diols obtained were protected as 4,4'-dimethoxytrityl ethers and subsequently activated as 2-cyanoethyl N,N-diisopropylchlorophosphoramidite in order to be suitable for oligonucleotide solid phase synthesis.

引用

页码：4635 / 4642

页数：8

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