Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses

被引：50

作者：

Gold, Diane R. ^{[2
]}

Bloomberg, Gordon R. ^{[3
]}

Cruikshank, William W. ^{[4
]}

Visness, Cynthia M. ^{[5
]}

Schwarz, John ^{[5
]}

Kattan, Meyer ^{[6
]}

O'Connor, George T. ^{[4
]}

Wood, Robert A. ^{[7
]}

Burger, Melissa S.

Wright, Rosalind J. ^{[2
]}

Witter, Frank ^{[7
]}

Lee-Parritz, Aviva ^{[4
]}

Sperling, Rhoda ^{[8
]}

Sadovsky, Yoel ^{[9
]}

Togias, Alkis ^{[10
]}

Gern, James E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Pediat, Sch Med & Publ Hlth, Ctr Clin Sci, Madison, WI 53792 USA

[2] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA

[3] Washington Univ, Sch Med, St Louis, MO USA

[4] Boston Univ, Sch Med, Boston, MA 02118 USA

[5] Rho Fed Syst Div Inc, Chapel Hill, NC USA

[6] Columbia Univ, Sch Med, New York, NY USA

[7] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[8] Mt Sinai Sch Med, New York, NY USA

[9] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[10] NIAID, Bethesda, MD 20892 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2009年 / 124卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Atopy; immune response; cord blood; birth cohort; gestational age; cytokines; INTERFERON-GAMMA PRODUCTION; HUMAN IMMUNE-SYSTEM; ENVIRONMENTAL ALLERGENS; POSTNATAL-DEVELOPMENT; CHILDHOOD ASTHMA; ATOPIC DISEASE; UNITED-STATES; 1ST YEAR; SENSITIZATION; PREDICTOR;

D O I：

10.1016/j.jaci.2009.08.021

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Immunologic responses at birth likely relate to subsequent risks for allergic diseases and wheezing in infancy; however, the influences of parental characteristics and prenatal factors on neonatal immune responses are incompletely understood. Objective: This study investigates potential correlations between urban parental, prenatal, and perinatal factors on innate and adaptive stimuli-induced cytokine responses. Methods: Five hundred sixty and 49 children of parents with and without allergic disease or asthma, respectively, were enrolled into a prospective birth cohort study (Urban Environment and Childhood Asthma). Cord blood mononuclear cells were incubated with innate and adaptive immune stimuli, and cytokine responses (ELISA) were compared with season of birth, parental characteristics, in utero stressors, and fetal growth. Results: Many cytokine responses varied by season of birth, including 2-fold to 3-fold fluctuations with specific IFN-alpha and IFN-gamma responses. Birth weight was inversely associated with IFN-gamma responses to respiratory syncytial virus.(R = -0.16), but positively associated with IL-8 responses to a variety of innate stimuli (R = 0.08-0.12). Respiratory syncytial virus-induced cytokine responses were 21% to 54% lower in children of mothers with asthma. Cytokine responses were generally lower in babies born to parents with allergy/asthma. Conclusions: Innate cytokine responses are associated with parental allergic or airway disease, somatic fetal growth, ethnicity, and season of birth. Collectively, these findings suggest that urban prenatal exposures and familial factors affect the development of the fetal immune system. (J Allergy Clin Immunol 2009;124:1078-87.)

引用

页码：1078 / 1087

页数：10