Genetic characterization of H1N1 swine influenza A viruses isolated in eastern China

被引：34

作者：

Qi, X. ^{[1
]}

Pang, B. ^{[1
]}

Lu, C. P. ^{[1
]}

机构：

[1] Nanjing Agr Univ, Minist Agr, Key Lab Anim Dis Diagnost & Immunol, Nanjing 210095, Jiangsu Prov, Peoples R China

来源：

VIRUS GENES | 2009年 / 39卷 / 02期

关键词：

Influenza A virus; H1N1; Swine; Genetic characterization; PIGS; H5N1; EVOLUTION; DETERMINANT; CONTRIBUTES; RECEPTOR; PROTEIN; PB1-F2;

D O I：

10.1007/s11262-009-0375-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Three influenza H1N1 viruses were isolated in 2005 from pigs with respiratory disease on a farm in eastern China. The three isolates were characterized to determine their probable origin. Each of the eight genes of the isolates was most closely related to the corresponding gene from the classical swine H1N1 virus. Also, phylogenetic analysis further confirmed that each of the eight genes of the isolates was closely related to the classical swine H1N1 viruses, especially those isolated in China. The HA1 proteins of the three isolates were identical to that of A/Swine/Guangdong/1/01, a virus isolated in 2001 in China, even though three nucleotide differences were observed. These results further support the concept that swine can serve as a reservoir of genetically stable influenza viruses.

引用

页码：193 / 199

页数：7

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