Deciphering the genetic landscape of cancer - from genes to pathways

被引：24

作者：

Copeland, Neal G. ^{[1
]}

Jenkins, Nancy A. ^{[1
]}

机构：

[1] Agcy Sci Technol & Res, Inst Mol & Cell Biol, Genom & Genet Div, Proteos 138673, Singapore

来源：

TRENDS IN GENETICS | 2009年 / 25卷 / 10期

关键词：

HUMAN BREAST; MUTATIONAL ANALYSIS; SOMATIC MUTATIONS; MUTAGENESIS; SCREEN; REARRANGEMENTS; PATTERNS; GENOME; FAMILY; MICE;

D O I：

10.1016/j.tig.2009.08.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Advances in genomic technologies have made it possible to screen the entire cancer genome for mutations, leading to a better understanding of the genetic landscape of cancer. Emerging results suggest that the cancer genome is composed of a few commonly mutated genes and many infrequently mutated genes. Although the number of mutated genes in any one tumor is limited, there is much heterogeneity in the genes mutated in two tumors of even the same class because of the large number of infrequently mutated genes. This could explain the wide variation in tumor behavior to chemotherapeutic intervention. Pathway analysis suggests this large collection of cancer genes functions in a few signaling pathways, providing a simplifying picture of cancer, and indicating the possibility of treating cancer using target-based therapeutics directed against the deregulated signaling pathways themselves rather than the individually mutated genes.

引用

页码：455 / 462

页数：8

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