Informatic identification of blocks of ordered nucleotide sequences in human chromosome 22

被引：1

作者：

Amano, N

Minezaki, Y

Suzuki, M

机构：

[1] AIST, Tsukuba, Ibaraki 3058566, Japan

[2] Univ Tsukuba, Doctoral Program Med Sci, Tsukuba, Ibaraki 3050006, Japan

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2002年 / 78卷 / 07期

关键词：

chromosome structure; human genome; information content; pattern recognition; repeat sequence;

D O I：

10.2183/pjab.78.205

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Using the draft sequence of human chromosome 22, blocks with a minimum length of 2K, in which combinations of bases are ordered to degrees higher than the rest, have been mathematically identified. Approximately 400 blocks are characterized with significantly low entropy values for combining 4-9 nucleotides each of the 4 types. These blocks span similar to3.5K bases on average, and altogether occupy 2.0-2.5% of this chromosome. The draft sequence extends from the end of the centromere to the beginning of the telomere, and the occupancy by identified blocks is highest near the two ends, and decreases while shifting nearer to the center.

引用

页码：205 / 210

页数：6

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