Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes

被引：250

作者：

Cadieu, Edouard ^{[1
]}

Neff, Mark W. ^{[2
]}

Quignon, Pascale ^{[1
]}

Walsh, Kari ^{[2
]}

Chase, Kevin ^{[3
]}

Parker, Heidi G. ^{[1
]}

VonHoldt, Bridgett M. ^{[4
]}

Rhue, Alison ^{[2
]}

Boyko, Adam ^{[5
]}

Byers, Alexandra ^{[1
]}

Wong, Aaron ^{[2
]}

Mosher, Dana S. ^{[1
]}

Elkahloun, Abdel G. ^{[1
]}

Spady, Tyrone C. ^{[1
]}

Andre, Catherine ^{[7
]}

Lark, K. Gordon ^{[3
]}

Cargill, Michelle ^{[6
]}

Bustamante, Carlos D. ^{[5
]}

Wayne, Robert K. ^{[4
]}

Ostrander, Elaine A. ^{[1
]}

机构：

[1] NHGRI, NIH, Bethesda, MD 20892 USA

[2] Univ Calif Davis, Vet Genet Lab, Davis, CA 95616 USA

[3] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA

[4] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA

[5] Cornell Univ, Dept Biol Stat & Computat Biol, Ithaca, NY 14853 USA

[6] Affymetrix Corp, Santa Clara, CA 95051 USA

[7] Univ Rennes 1, CNRS, Fac Med, UMR 6061, Rennes, France

来源：

SCIENCE | 2009年 / 326卷 / 5949期

基金：

美国国家科学基金会;

关键词：

MAJOR DETERMINANT; HAIR; MUTATIONS; FGF5; MULTIPLE; SEQUENCE; CYCLE;

D O I：

10.1126/science.1177808

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coat color and type are essential characteristics of domestic dog breeds. Although the genetic basis of coat color has been well characterized, relatively little is known about the genes influencing coat growth pattern, length, and curl. We performed genome-wide association studies of more than 1000 dogs from 80 domestic breeds to identify genes associated with canine fur phenotypes. Taking advantage of both inter- and intrabreed variability, we identified distinct mutations in three genes, RSPO2, FGF5, and KRT71 (encoding R-spondin-2, fibroblast growth factor-5, and keratin-71, respectively), that together account for most coat phenotypes in purebred dogs in the United States. Thus, an array of varied and seemingly complex phenotypes can be reduced to the combinatorial effects of only a few genes.

引用

页码：150 / 153

页数：4

共 25 条

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