Cell death in the inner nuclear layer of the retina is modulated by BDNF

被引：27

作者：

Cusato, K

Bosco, A

Linden, R

Reese, BE ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA

[2] Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA

[3] UFRJ, Inst Biofis, CCS, BR-21949900 Rio De Janeiro, Brazil

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2002年 / 139卷 / 02期

基金：

美国国家卫生研究院;

关键词：

pyknosis; neurotrophin; TrkB receptor; amacrine cell;

D O I：

10.1016/S0165-3806(02)00570-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Developing amacrine cells in the vertebrate retina undergo naturally-occurring cell death which is accentuated by the early removal of retinal ganglion cells. We show that providing BDNF or decreasing endogenous BDNF via competitive binding with soluble TrkB receptors in a whole-retina culture assay modulates the frequency of dying cells in the amacrine cell layer. Ganglion cells synthesize BDNF, and amacrine cells express TrkB receptors, suggesting a likely signaling mechanism. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：325 / 330

页数：6

共 37 条

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