Rhodium(II,II) dimer as an efficient catalyst for aziridination of sulfonamides and amidation of steroids

被引：128

作者：

Liang, JL

Yuan, SX

Chan, PWH

Che, CM

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 25期

关键词：

D O I：

10.1021/ol0270475

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Unsaturated sulfonamides underwent direct intramolecular aziridination catalyzed by Rh-2(OAc)(4) with PhI(OAC)(2) and Al2O3 to give the corresponding aziridine products in excellent yields (up to 98%) and with good to excellent conversions. High turnovers (up to 1375) were achieved. The intermolecular rhodium-catalyzed amidation of cholesteryl acetate with PhI=NTs or Phi(OAc)(2)/NH2R as the nitrogen source exhibited both excellent regio- and alpha-selectivity (alpha/beta ratio up to 9:1).

引用

页码：4507 / 4510

页数：4

共 47 条

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