Anxiety and depression are related to autonomic nervous system function in women with irritable bowel syndrome

被引:95
作者
Jarrett, ME
Burr, RL
Cain, KC
Hertig, V
Weisman, P
Heitkemper, MM
机构
[1] Univ Washington, Dept Biobehav Nursing & Hlth Syst, Seattle, WA 98195 USA
[2] Univ Washington, Dept Biostat, Seattle, WA 98195 USA
[3] Univ Washington, Off Nursing Res, Seattle, WA 98195 USA
关键词
depression; anxiety; autonomic nervous system; parasympathetic nervous system; irritable bowel syndrome;
D O I
10.1023/A:1021904216312
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
This study compared women with irritable bowel syndrome who had a history of an anxiety or depressive disorder to those without symptoms of either disorder on indicators of cardiac parasympathetic activity, autonomic nervous system balance, and general autonomic activity. The Diagnostic Interview Schedule was used to determine anxiety or depressive disorders, and a Holter monitor was used to record R-R intervals over 24 hr. A similar comparison was done with healthy controls. Among women with irritable bowel syndrome, those with a positive history had lower parasympathetic and general activity throughout the 24-hr period than did women without a diagnosis. Indicators of autonomic balance were slightly higher in women with a positive history compared to those without a history. Similar differences were seen in controls. Thus, a history of anxiety and depressive disorders is associated with lower parasympathetic activity, both in women with IBS and healthy controls. Further exploration is needed to understand if lower parasympathetic activity influences the pain and stool pattern changes seen in persons with irritable bowel syndrome.
引用
收藏
页码:386 / 394
页数:9
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