Bronchopulmonary dysplasia: new insights

被引：40

作者：

Ambalavanan, N ^{[1
]}

Carlo, WA ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Pediat, Div Neonatol, Birmingham, AL 35233 USA

来源：

CLINICS IN PERINATOLOGY | 2004年 / 31卷 / 03期

关键词：

D O I：

10.1016/j.clp.2004.05.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The pathology of bronchopulmonary dysplasia (BPD) has changed over time. Previously characterized by airway injury, inflammation, and parenchymal fibrosis, BPD now manifests less fibrosis but with decreased alveolar and vascular development. The pathogenesis of BPD involves factors affecting the severity and management of respiratory distress syndrome, alterations in lung development and maturation, alveolar-vascular interactions, and extracellular matrix remodeling. These factors in pathogenesis are mediated and modulated by hyperoxic lung injury, antioxidants, nitric oxide, the pulmonary neuroendocrine system and peptide growth factors, the immune system, and various genetic polymorphisms and predispositions. Future therapeutic interventions are likely to target one or more of these abnormalities in lung development, maturation, and response to injury.

引用

页码：613 / +

页数：17

共 123 条

[1] Bronchopulmonary dysplasia - "A vascular hypothesis" [J].

Abman, SH .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (10) :1755-1756

[2] The TNF-α-308, MCP-1-2518 and TGF-β1+915 polymorphisms are not associated with the development of chronic lung disease in very low birth weight infants [J].

Adcock, K ;

Hedberg, C ;

Loggins, J ;

Kruger, TE ;

Baier, RJ .

GENES AND IMMUNITY, 2003, 4 (06) :420-426

[3] Basement membrane biomarkers in very low birth weight premature infants - Association with length of NICU stay and bronchopulmonary dysplasia [J].

Aghai, ZH ;

Arevalo, R ;

Lumicao, L ;

Lesser, M ;

Shi, QH ;

Jain, A ;

Krauss, AN ;

Auld, PAM ;

Hanauske-Abel, HM .

BIOLOGY OF THE NEONATE, 2002, 81 (01) :16-22

[4] N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants:: A randomized controlled trial [J].

Ahola, T ;

Lapatto, R ;

Raivio, KO ;

Selander, B ;

Stigson, L ;

Jonsson, B ;

Jonsbo, F ;

Esberg, G ;

Stövring, S ;

Kjartansson, S ;

Stiris, T ;

Lossius, K ;

Virkola, K ;

Fellman, V .

JOURNAL OF PEDIATRICS, 2003, 143 (06) :713-719

[5] Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates [J].

Ambalavanan, N ;

Novak, ZE .

PEDIATRIC RESEARCH, 2003, 53 (02) :240-244

[6]

Ambalayanan N, 2004, PEDIATR RES, V55, p443A

[7]

[Anonymous], 2003, COCHRANE DB SYST REV

[8] Expression and developmental profile of antioxidant enzymes in human lung and liver [J].

Asikainen, TM ;

Raivio, KO ;

Saksela, M ;

Kinnula, VL .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 19 (06) :942-949

[9] Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: Implications for antioxidant therapy [J].

Asikainen, TM ;

White, CW .

ANTIOXIDANTS & REDOX SIGNALING, 2004, 6 (01) :155-167

[10]

Auten RL, 2001, J PHARMACOL EXP THER, V299, P90

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