Breast tumor vascularity identified by contrast enhanced ultrasound and pathology: initial results

被引:49
作者
Chaudhari, MH
Forsberg, F [1 ]
Voodarla, A
Saikali, FN
Goonewardene, S
Needleman, L
Finkel, GC
Goldberg, BB
机构
[1] Thomas Jefferson Univ, Dept Radiol, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Dept Pathol, Philadelphia, PA 19107 USA
关键词
color flow imaging; image processing; tumor neovascularity; ultrasound contrast agents;
D O I
10.1016/S0041-624X(99)00146-8
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
Quantifiable measures of vascularity obtained from contrast enhanced color flow images were correlated with pathologic vascularity measurements in ten female patients with a solid breast mass. Each patient received Levovist Injection(R) (Berlex Laboratories Inc., Montville, NJ). Color flow images pre- and post-contrast were obtained using an HDI 3000 unit (ATL, Bothell, WA) before removing the mass for pathologic vascularity assessments. Image-processing techniques were used to obtain both the ultrasound and pathologic vascularity measurements. Multiple linear regression found significant correlations for ultrasonic vascularity measurements post contrast and pathology (P=0.02 and 0.06). No correlations were found between pre-contrast ultrasound and pathology. In conclusion, post-contrast ultrasonic flow measures provide a non-invasive measure of breast tumor neovascularity. However, the patient population is small, and until further patients are analyzed, these conclusions are preliminary. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:105 / 109
页数:5
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