Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance

被引：65

作者：

Burg, D ^{[1
]}

Mulder, GJ ^{[1
]}

机构：

[1] Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, Netherlands

来源：

DRUG METABOLISM REVIEWS | 2002年 / 34卷 / 04期

关键词：

GSH; GST; MRP; gamma GT; DNA-PK;

D O I：

10.1081/DMR-120015695

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alterations in levels of glutathione (GSH) and glutathione-dependent enzymes have been implicated in cancer and multidrug resistance of tumor cells. The activity of a number of these, the multidrug resistance-associated protein 1, glutathione S-transferase, DNA-dependent protein kinase, glyoxalase I, and gamma-glutamyl transpeptidase, can be inhibited by GSH-conjugates and synthetic analogs thereof. In this review we focus on the function of these enzymes and carriers in cancer and anti-cancer drug resistance, in relation to their inhibition by GSH-conjugate analogs.

引用

页码：821 / 863

页数：43

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