Therapeutic and biological importance of getting nucleotides out of cells: a case for the ABC transporters, MRP4 and 5

被引：45

作者：

Adachi, M

Reid, G

Schuetz, JD

机构：

[1] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

[2] Netherlands Canc Inst, NL-1006 CX Amsterdam, Netherlands

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2002年 / 54卷 / 10期

关键词：

D O I：

10.1016/S0169-409X(02)00166-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The energy dependent transport of drugs contributes to cellular resistance and is undoubtedly a prime suspect in chemotherapeutic failure of a variety of disease processes. Early studies focused on a single gene, the multidrug resistance gene, MDR1, as a main contributor to chemotherapeutic failure. However, the multifaceted nature of cellular resistance lead to the discovery of the MRP gene. This pivotal finding and the concurrent rapid development of gene databases lead to the expansion of the MRP gene family. The purpose of this review is to discuss two of the recently described MRP family members that were orphans until their role in drug resistance was discovered. This review will provide an overview of the current state of our understanding of MRP4 and 5. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：1333 / 1342

页数：10

相关论文

共 57 条

[1] Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing [J].

Adachi, M ;

Sampath, J ;

Lan, LB ;

Sun, DX ;

Hargrove, P ;

Flatley, R ;

Tatum, A ;

Edwards, MZ ;

Wezeman, M ;

Matherly, L ;

Drake, R ;

Schuetz, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (41) :38998-39004

[2] Characterization of the human ABC superfamily: Isolation and mapping of 21 new genes using the expressed sequence tags database [J].

Allikmets, R ;

Gerrard, B ;

Hutchinson, A ;

Dean, M .

HUMAN MOLECULAR GENETICS, 1996, 5 (10) :1649-1655

[3] 9-[(2RS)-3-FLUORO-2-PHOSPHONYLMETHOXYPROPYL] DERIVATIVES OF PURINES - A CLASS OF HIGHLY SELECTIVE ANTIRETROVIRAL AGENTS INVITRO AND INVIVO [J].

BALZARINI, J ;

HOLY, A ;

JINDRICH, J ;

DVORAKOVA, H ;

HAO, Z ;

SNOECK, R ;

HERDEWIJN, P ;

JOHNS, DG ;

DECLERCQ, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :4961-4965

[4] The thymidine kinase ganciclovir-mediated ''suicide'' effect is variable in different tumor cells [J].

Beck, C ;

Cayeux, S ;

Lupton, SD ;

Dorken, B ;

Blankenstein, T .

HUMAN GENE THERAPY, 1995, 6 (12) :1525-1530

[5] MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer [J].

Bera, TK ;

Iavarone, C ;

Kumar, V ;

Lee, S ;

Lee, B ;

Pastan, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (10) :6997-7002

[6] A family of drug transporters: The multidrug resistance-associated proteins [J].

Borst, P ;

Evers, R ;

Kool, M ;

Wijnholds, J .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (16) :1295-1302

[7]

Butcher R W, 1968, Adv Enzyme Regul, V6, P357, DOI 10.1016/0065-2571(68)90023-X

[8] Transport of cyclic nucleotides and estradiol 17-β-D-glueuronide by multidrug resistance protein 4 -: Resistance to 6-mercaptopurine and 6-thioguanine [J].

Chen, ZS ;

Lee, K ;

Kruh, GD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :33747-33754

[9]

CHILDS S, 1995, CANCER RES, V55, P2029

[10] OVEREXPRESSION OF A TRANSPORTER GENE IN A MULTIDRUG-RESISTANT HUMAN LUNG-CANCER CELL-LINE [J].

COLE, SPC ;

BHARDWAJ, G ;

GERLACH, JH ;

MACKIE, JE ;

GRANT, CE ;

ALMQUIST, KC ;

STEWART, AJ ;

KURZ, EU ;

DUNCAN, AMV ;

DEELEY, RG .

SCIENCE, 1992, 258 (5088) :1650-1654

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