Cytoplasmic lipid droplets - Rediscovery of an old structure as a unique platform

被引：50

作者：

Fujimoto, Toyoshi ^{[1
]}

Ohsaki, Yuki ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Anat & Mol Cell Biol, Nagoya, Aichi 4668550, Japan

来源：

INTEGRATED MOLECULAR MEDICINE FOR NEURONAL AND NEOPLASTIC DISORDERS | 2006年 / 1086卷

关键词：

lipid droplet; ADRP; Rab18; autophagy; proteasome; apolipoprotein B; alpha-synuclein;

D O I：

10.1196/annals.1377.010

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cytoplasmic lipid droplets (LDs) exist in virtually any kind of cell. They have a core of lipid esters covered by the surface phospholipid monolayer. A number of proteins related to various cell functions are present in LDs and/or LD-rich subcellular fractions, suggesting that LDs are an independent organelle that is engaged in various cellular activities. Furthermore, a recent study suggested that LDs are a platform where the proteasomal and autophagic pathways converge. The molecular composition and architecture of LDs are discussed here, with special reference to the technical difficulties encountered when analyzing this unique organelle.

引用

页码：104 / 115

页数：12

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