PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model

被引：27

作者：

Leonard, CT

Soccal, PM

Berry, GJ

Doyle, RL

Theodore, J

Duncan, SR

Rosen, GD

机构：

[1] Stanford Univ, Med Ctr, Div Pulm & Crit Care Med, Dept Histol, Stanford, CA 94305 USA

[2] Scripps Res Inst, Dept Immunol, San Diego, CA USA

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2002年 / 21卷 / 12期

关键词：

D O I：

10.1016/S1053-2498(02)00449-7

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The current treatment of obliterative bronchiolitis in lung transplant recipients is suboptimal. Triptolide is a novel immunosuppressant that has a mechanism of action distinct from currently available immunosuppressants, including induction of T-cell apoptosis, blockade of fibroblast proliferation/maturation and inhibition of transforming growth factor-beta (TGF-beta) mRNA production. We hypothesized that triptolide may be helpful in blocking obliterative airway disease in lung transplant recipients. We investigated the effect of PG490-88, a water-soluble derivative of triptolide, in a mouse heterotopic tracheal allograft model of obliterative airway disease. We show that PG490-88 attenuates airway obliteration in this model and inhibits accumulation of inflammatory cells, and therefore may have preventive or therapeutic benefits for patients with obliterative airway disease (OAD) following lung transplantation.

引用

收藏

页码：1314 / 1318

页数：5

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