Influence of the hepatitis C virus 3′-untranslated region on IRES-dependent and cap-dependent translation initiation

被引：48

作者：

Bung, C. ^{[1
]}

Bochkaeva, Z. ^{[2
]}

Terenin, I. ^{[2
]}

Zinovkin, R. ^{[3
]}

Shatsky, I. N. ^{[2
]}

Niepmann, M. ^{[1
]}

机构：

[1] Univ Giessen, Fac Med, Inst Biochem, D-35390 Giessen, Germany

[2] Moscow MV Lomonosov State Univ, AN Belozersky Inst Physicochem Biol, Moscow, Russia

[3] Moscow MV Lomonosov State Univ, Inst Mitoengn, Moscow, Russia

来源：

FEBS LETTERS | 2010年 / 584卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

Hepatitis C virus; Porcine teschovirus; 3 '-untranslated region; Poly(A); Picornavirus; Internal ribosome entry site; RIBOSOME ENTRY SITES; EUKARYOTIC TRANSLATION; POLY(A)-BINDING PROTEIN; ENHANCES TRANSLATION; RNA; PICORNAVIRUS; BINDING; TAIL; MODE;

D O I：

10.1016/j.febslet.2010.01.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Translation of hepatitis C virus (HCV) genomic RNA is directed by an internal ribosome entry site (IRES) in the 5'-untranslated region (5'-UTR), and the HCV 3'-UTR enhances IRES activity. Since the HCV 3'-UTR has a unique structure among 3'-UTRs, we checked possible communication between the 5'- and the 3'-UTR of HCV during translation using chimeric reporter RNAs. We show that translation directed by the HCV IRES and by the HCV-like IRES of porcine teschovirus (PTV) which belongs to a quite distinct family of viruses (picornaviruses) or by the EMCV IRES is also enhanced by the HCV 3'-UTR or by a poly(A)-tail in different cell types. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：837 / 842

页数：6

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