Role of genetic polymorphisms in tumour angiogenesis

被引：67

作者：

Balasubramanian, SP

Brown, NJ

Reed, MWR ^{[1
]}

机构：

[1] Univ Sheffield, Acad Unit Surg Oncol, Sheffield S10 2JF, S Yorkshire, England

[2] Univ Sheffield, Acad Unit Surg, Sheffield S10 2JF, S Yorkshire, England

来源：

BRITISH JOURNAL OF CANCER | 2002年 / 87卷 / 10期

关键词：

tumour angiogenesis; genetic polymorphism(s);

D O I：

10.1038/sj.bjc.6600625

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed. (C) 2002 Cancer Research UK.

引用

收藏

页码：1057 / 1065

页数：9

相关论文

共 107 条

[31] The role of fibroblasts in tumor behavior [J].

Gregoire, M ;

Lieubeau, B .

CANCER AND METASTASIS REVIEWS, 1995, 14 (04) :339-350

[32] Influence of TNFα gene polymorphisms on TNFα production and disease [J].

Hajeer, AH ;

Hutchinson, IV .

HUMAN IMMUNOLOGY, 2001, 62 (11) :1191-1199

[33] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 [J].

Hart, KC ;

Robertson, SC ;

Kanemitsu, MY ;

Meyer, AN ;

Tynan, JA ;

Donoghue, DJ .

ONCOGENE, 2000, 19 (29) :3309-3320

[34]

Hasegawa Y, 2001, CANCER-AM CANCER SOC, V91, P964, DOI 10.1002/1097-0142(20010301)91:5<964::AID-CNCR1086>3.0.CO

[35]

2-O

[36] Polymorphism of the 5′-flanking region of the human tumor necrosis factor (TNF)-α gene in Japanese [J].

Higuchi, T ;

Seki, N ;

Kamizono, S ;

Yamada, A ;

Kimura, A ;

Kato, H ;

Itoh, K .

TISSUE ANTIGENS, 1998, 51 (06) :605-612

[37] UROKINASE AND MACROPHAGES IN TUMOR ANGIOGENESIS [J].

HILDENBRAND, R ;

DILGER, I ;

HORLIN, A ;

STUTTE, HJ .

BRITISH JOURNAL OF CANCER, 1995, 72 (04) :818-823

[38] Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma [J].

Howell, WM ;

Bateman, A ;

Turner, SJ ;

Collins, A ;

Theaker, JM .

GENES AND IMMUNITY, 2002, 3 (04) :229-232

[39] IL-10 promoter polymorphisms influence tumour development in cutaneous malignant melanoma [J].

Howell, WM ;

Turner, SJ ;

Bateman, AC ;

Theaker, JM .

GENES AND IMMUNITY, 2001, 2 (01) :25-31

[40]

Iughetti P, 2001, CANCER RES, V61, P7375

← 1 2 3 4 5 6 7 8 9 10 →