EPR study of free radicals in some drugs γ-irradiated in the solid state

被引：37

作者：

Ambroz, HB

Kornacka, EM

Marciniec, B

Ogrodowczyk, M

Przybytniak, GK

机构：

[1] Inst Nucl Chem & Technol, PL-03195 Warsaw, Poland

[2] K Marcinkowski Univ Med Sci, Dept Pharmaceut Chem, PL-60780 Poznan, Poland

来源：

RADIATION PHYSICS AND CHEMISTRY | 2000年 / 58卷 / 04期

关键词：

gamma-irradiation of drugs; EPR spectroscopy; free radicals;

D O I：

10.1016/S0969-806X(99)00489-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 [物理化学]; 081704 [应用化学];

摘要：

A range of drugs in the form of microcrystalline powder was exposed to gamma-radiation. EPR measurements proved that all of them contained various paramagnetic species after 4 and 8 weeks of storage. We observed following radical concentrations, stable up to 4 weeks: the highest for ifosfamide - 4.5 x 10(17) spins per gram and the lowest for nimodipine - 2.1 x 10(16) spins per gram. Three drugs exhibited very weak EPR signals before irradiation, not detectable quantitatively. Some spectroscopic properties and suggestions concerning possible structure of the radicals are given in our paper. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：357 / 366

页数：10

共 14 条

[1]

Effects of gamma irradiation on physicochemical properties of Korean red ginseng powder [J].