Surface-Treatment-Induced Three-Dimensional Capillary Morphogenesis in a Microfluidic Platform

被引：70

作者：

Chung, Seok ^{[3
]}

Sudo, Ryo ^{[4
]}

Zervantonakis, Ioannis K. ^{[1
,2
]}

Rimchala, Tharathorn ^{[1
,2
]}

Kamm, Roger D. ^{[1
,2
]}

机构：

[1] MIT, Dept Engn Mech, Cambridge, MA 02139 USA

[2] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[3] Korea Univ, Sch Mech Engn, Seoul 136713, South Korea

[4] Keio Univ, Dept Syst Design Engn, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 47期

基金：

美国国家科学基金会;

关键词：

ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS IN-VITRO; CELL-MIGRATION; COLLAGEN MATRICES; CULTURE; 3D; HYDROGEL; DEVICE; EXPRESSION; ENVIRONMENTS;

D O I：

10.1002/adma.200901727

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Robust induction of realistic angiogenesis into a 3D matrix material under simultaneous imaging and a stably controlled concentration gradient of chemoattractants is presented. The formation of a 3D vascular network is demonstrated to be a direct consequence of surface treatment of the region of the device-containing matrix material.

引用

收藏

页码：4863 / +

页数：6

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