Carotid atherosclerosis in men with low levels of HDL cholesterol

被引:29
作者
Wilt, TJ
Rubins, HB
Robins, SJ
Riley, WA
Collins, D
Elam, M
Rutan, G
Anderson, JW
机构
[1] UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN 55455
[2] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT NEUROL,WINSTON SALEM,NC 27103
[3] VET AFFAIRS MED CTR,DEPT MED,BOSTON,MA
[4] BOSTON UNIV,SCH MED,BOSTON,MA 02215
[5] VA COOPERAT STUDIES COORDINATING CTR,W HAVEN,CT
[6] VET AFFAIRS MED CTR,SECT ENDOCRINOL,LEXINGTON,KY
[7] VET AFFAIRS MED CTR,DEPT MED,MEMPHIS,TN
[8] VET AFFAIRS MED CTR,GEN INTERNAL MED SECT,MEMPHIS,TN
[9] VET AFFAIRS MED CTR,CARDIOL SECT,MEMPHIS,TN
[10] UNIV TENNESSEE,KNOXVILLE,TN 37996
关键词
carotid artery diseases; cholesterol; epidemiology; ultrasonics;
D O I
10.1161/01.STR.28.10.1919
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose A low HDL cholesterol (HDL-C) frequently occurs in conjunction with a desirable LDL cholesterol (LDL-C) and is a risk factor for coronary heart disease (CHD). Additionally, the presence of carotid atherosclerosis is a strong and independent predictor of morbidity and mortality in patients with CHD. This article describes the prevalence and correlates of sonographically detected carotid atherosclerosis in men with low levels of HDL-C and CHD but without elevated levels of LDL-C or total cholesterol. Methods High-resolution B-mode ultrasonography was used to quantify intima-media wall thickness (IMT) in the common and internal carotid arteries and at the carotid artery bifurcation in 202 randomly selected male veterans with CHD and low levels of HDL-C who are participating in the VA HDL Intervention Trial. Ultrasonographic measurement of carotid artery wall stiffness was determined in a subset of 94 of these individuals. Results The mean maximum and single greatest carotid artery IMT measurements were 1.41 and 2.58 mm, respectively. The prevalence of ultrasound-detected carotid atherosclerosis as defined by a mean maximum IMT greater than or equal to 1.3 mm was 58.9% and by single maximum IMT greater than or equal to 1.5 mm was 87.1%. IMT was associated with increased age, lower extremity arterial disease, systolic blood pressure, and ultrasonographically measured carotid artery stiffness. Conclusions Men with low levels of HDL-C and CHD but without elevated LDL-C or total cholesterol have a very high prevalence of ultrasound-detected carotid artery atherosclerosis.
引用
收藏
页码:1919 / 1925
页数:7
相关论文
共 42 条
[1]  
ADAMS MR, 1994, CIRCULATION, V90, P23
[2]   MIDAS, THE MULTICENTER ISRADIPINE DIURETIC ATHEROSCLEROSIS STUDY - DESIGN-FEATURES AND BASE-LINE DATA [J].
APPLEGATE, WB ;
BYINGTON, RP .
AMERICAN JOURNAL OF HYPERTENSION, 1991, 4 (02) :S114-S117
[3]   ARTERIAL STIFFNESS - A NEW CARDIOVASCULAR RISK FACTOR [J].
ARNETT, DK ;
EVANS, GW ;
RILEY, WA .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1994, 140 (08) :669-682
[4]   CHOLESTEROL REDUCTION AND THE RISK FOR STROKE IN MEN - A METAANALYSIS OF RANDOMIZED, CONTROLLED TRIALS [J].
ATKINS, D ;
PSATY, BM ;
KOEPSELL, TD ;
LONGSTRETH, WT ;
LARSON, EB .
ANNALS OF INTERNAL MEDICINE, 1993, 119 (02) :136-145
[5]   REPRODUCIBILITY OF CAROTID VESSEL WALL THICKNESS MEASUREMENTS - THE ROTTERDAM STUDY [J].
BOTS, ML ;
MULDER, PGH ;
HOFMAN, A ;
VANES, GA ;
GROBBEE, DE .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 1994, 47 (08) :921-930
[6]   MEDICAL PROGRESS - PRIMARY PREVENTION OF STROKE [J].
BRONNER, LL ;
KANTER, DS ;
MANSON, JE .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (21) :1392-1400
[7]   MORTALITY OVER A PERIOD OF 10 YEARS IN PATIENTS WITH PERIPHERAL ARTERIAL-DISEASE [J].
CRIQUI, MH ;
LANGER, RD ;
FRONEK, A ;
FEIGELSON, HS ;
KLAUBER, MR ;
MCCANN, TJ ;
BROWNER, D .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (06) :381-386
[8]   PRAVASTATIN, LIPIDS, AND ATHEROSCLEROSIS IN THE CAROTID ARTERIES (PLAC-II) [J].
CROUSE, JR ;
BYINGTON, RP ;
BOND, MG ;
ESPELAND, MA ;
CRAVEN, TE ;
SPRINKLE, JW ;
MCGOVERN, ME ;
FURBERG, CD .
AMERICAN JOURNAL OF CARDIOLOGY, 1995, 75 (07) :455-459
[9]   LONG-TERM SURVIVAL IN PATIENTS WITH CORONARY-ARTERY DISEASE - IMPORTANCE OF PERIPHERAL VASCULAR-DISEASE [J].
EAGLE, KA ;
RIHAL, CS ;
FOSTER, ED ;
MICKEL, MC ;
GERSH, BJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 23 (05) :1091-1095
[10]  
*EX COMM AS CAR AT, 1995, JAMA-J AM MED ASSOC, V273, P1421