Effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus B3 myocarditis

被引：54

作者：

Zhang, Z.-C.

Li, S.-J.

Yang, Y.-Z.

Chen, R.-Z.

Ge, J.-B.

Chen, H.-Z.

机构：

[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Minist Publ Hlth,Key Lab Viral Heart Dis, Shanghai 200032, Peoples R China

[2] Zhejiang Hosp, Hangzhou 310013, Zhenjiang Provi, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2007年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

astragaloside; apoptosis; coxsackievirus B (CVB); myocarditis; microarray;

D O I：

10.1080/10286020412331286506

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Astragaloside is the major component of Astragalus membranaceus, one of the Chinese medical herbs, and has several pharmacological actions on cardiovascular system, including positive inotropic, antiarrhythmia and anti-oxidant activities. We have investigated the effect of astragaloside on cardiomyocyte apoptosis and expression of apoptosis-associated genes in mice with coxsackievirus B-3 (CVB3)-induced myocarditis, the former of which has been detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end-labeling (TUNEL) assay and the latter determined by using a focused microarray. Results showed that cardiomyocyte apoptosis and expression of various apoptosis associated genes are inhibited after treatment with astragaloside. The anti-apoptotic activity of astragaloside may contribute to the improvement of clinical outcomes in treating myocarditis with pharmaceutics of Astragalus membranaceus.

引用

页码：145 / 151

页数：7

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