Gastrointestinal factors regulating lipid droplet formation in the intestine

被引：14

作者：

Auclair, N. ^{[1
,2
,3
]}

Melbouci, L. ^{[1
,2
,4
]}

St-Pierre, D. ^{[1
,2
,4
]}

Levy, E. ^{[1
,2
,3
,5
]}

机构：

[1] CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] Dept Montreal, Montreal, PQ H3T 1C5, Canada

[3] Univ Montreal, Nutr, Montreal, PQ H3T 1C5, Canada

[4] UQAM, Dept Sci & Phys Activ, Quebec City, PQ H2X 1Y4, Canada

[5] Univ Laval, Inst Nutr & Funct Foods INAF, Quebec City, PQ G1V 0A6, Canada

来源：

EXPERIMENTAL CELL RESEARCH | 2018年 / 363卷 / 01期

关键词：

Chylomicrons; Lipid droplets; Gastrointestinal peptides; Intestine; Lipid metabolism; Enterocytes; GLUCAGON-LIKE PEPTIDE-1; ACTIVATED PROTEIN-KINASE; ACID-BINDING PROTEIN; LOW-DENSITY LIPOPROTEIN; PANCREATIC BETA-CELL; WHITE ADIPOSE-TISSUE; FATTY-ACID; INSULIN-RESISTANCE; TRANSCRIPTION FACTORS; GENE-EXPRESSION;

D O I：

10.1016/j.yexcr.2017.12.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cytoplasmic lipid droplets (CLD) are considered as neutral lipid reservoirs, which protect cells from lipotoxicity. It became clear that these fascinating dynamic organelles play a role not only in energy storage and metabolism, but also in cellular lipid and protein handling, inter-organelle communication, and signaling among diverse functions. Their dysregulation is associated with multiple disorders, including obesity, liver steatosis and cardiovascular diseases. The central aim of this review is to highlight the link between intra-enterocyte CLD dynamics and the formation of chylomicrons, the main intestinal dietary lipid vehicle, after overviewing the morphology, molecular composition, biogenesis and functions of CLD.

引用

页码：1 / 14

页数：14

共 266 条

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