Block lengths and block sequence of linear triblock and glycerol derivative diblock copolyethers by electrospray ionization -: Collision-induced dissociation mass spectrometry

被引:26
作者
Terrier, P [1 ]
Buchmann, W [1 ]
Desmazières, B [1 ]
Tortajada, J [1 ]
机构
[1] Univ Evry Val Essonne, Lab Anal & Modelisat Biol & Environm, CNRS, UMR 8587, F-91025 Evry, France
关键词
D O I
10.1021/ac051308h
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Chemical properties of ethylene oxide (EO) and propylene oxide (PO) block copolymers are strongly dependent on their sequence. Useful information about copolymer sequence can be obtained by tandem mass spectrometry (MS/MS). In this work, collision-induced dissociation (CID) of ammonium adducts of various linear triblock and glycerol derivative diblock copolyethers produced by electrospray ionization was studied under low-energy conditions. At first, homopolymers MS/MS spectra enabled us to identify the nature of the product ions and to suggest decomposition pathways. Then, it was shown that copolyethers with the same composition in each repeat unit but with inversed block sequences (i.e., PEO-b-PPOb-PEO vs PPO-b-PEO-b-PPO and gPEO-b-PPO vs gPPOb-PEO) can be easily distinguished with characteristic fragment ions. In the case of linear copolymers, CID spectra gave pertinent information about block lengths.
引用
收藏
页码:1801 / 1806
页数:6
相关论文
共 27 条
[1]   Determination of end groups of synthetic polymers by matrix-assisted laser desorption/ionization: High-energy collision-induced dissociation [J].
Bottrill, AR ;
Giannakopulos, AE ;
Waterson, C ;
Haddleton, DM ;
Lee, KS ;
Derrick, PJ .
ANALYTICAL CHEMISTRY, 1999, 71 (17) :3637-3641
[2]   Sequencing of specific copolymer oligomers by electron-capture-dissociation mass spectrometry [J].
Cerda, BA ;
Horn, DM ;
Breuker, K ;
McLafferty, FW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (31) :9287-9291
[3]   Characterization of poly(ethylene glycol) esters using low energy collision-induced dissociation in electrospray ionization mass spectrometry [J].
Chen, R ;
Yu, XL ;
Li, L .
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2002, 13 (07) :888-897
[4]   Lithium and transition metal ions enable low energy collision-induced dissociation of polyglycols in electrospray ionization mass spectrometry [J].
Chen, R ;
Li, L .
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2001, 12 (07) :832-839
[5]   Application of an integrated matrix-assisted laser desorption/ionization time-of-flight, electrospray ionization mass spectrometry and tandem mass spectrometry approach to characterizing complex polyol mixtures [J].
Chen, R ;
Tseng, AM ;
Uhing, M ;
Li, L .
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2001, 12 (01) :55-60
[6]   MALDI PSD of low molecular weight ethoxylated polymers [J].
Hanton, SD ;
Parees, DA ;
Owens, KG .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2004, 238 (03) :257-264
[7]   Microstructural and conformational studies of polyether copolymers [J].
Jackson, AT ;
Scrivens, JH ;
Williams, JP ;
Baker, ES ;
Gidden, J ;
Bowers, MT .
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2004, 238 (03) :287-297
[8]  
Jackson AT, 1996, RAPID COMMUN MASS SP, V10, P1668, DOI 10.1002/(SICI)1097-0231(199610)10:13<1668::AID-RCM703>3.0.CO
[9]  
2-I
[10]   Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery [J].
Kabanov, AV ;
Batrakova, EV ;
Alakhov, VY .
JOURNAL OF CONTROLLED RELEASE, 2002, 82 (2-3) :189-212