Effects of benzodiazepine receptor ligands on isolated rat superior cervical ganglia neurons

被引：3

作者：

Aguayo, LG ^{[1
]}

Cisternas, C ^{[1
]}

Tapia, JC ^{[1
]}

Pancetti, FC ^{[1
]}

机构：

[1] PONTIFICIA UNIV CATOLICA VALPARAISO, INST CHEM, NEUROPHARMACOL LAB, VALPARAISO, CHILE

来源：

PHARMACOLOGY | 1996年 / 52卷 / 06期

关键词：

GABA(A) receptor; benzodiazepine receptor; diazepam; CL 218,872; Ro; 15-1788; Cl-; current; superior cervical ganglion;

D O I：

10.1159/000139404

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the effects of diazepam, CL 218,872, Ro 15-1788, beta-CCM and Ro 15-4513 on the gamma-aminobutyric acid-activated current in adult and newborn rat superior cervical ganglion neurons. Diazepam (10-1,000 nmol/l) potentiated the current in a concentration-dependent manner. CL 218,872 was less effective and weaker than diazepam. The other ligands reduced the amplitude of the current. These peripheral receptors might be involved in some of the side effects of benzodiazepines.

引用

页码：371 / 376

页数：6

共 20 条

[1]

AGUAYO LG, 1993, J PHARMACOL EXP THER, V267, P1414

[2]

CHAN CY, 1985, J NEUROSCI, V5, P2365

[3] EVIDENCE FOR GABAERGIC FIBERS ENTERING THE SUPERIOR CERVICAL-GANGLION OF RAT FROM THE PREGANGLIONIC NERVE TRUNK [J].

DOBO, E ;

KASA, P ;

WENTHOLD, RJ ;

JOO, F ;

WOLFF, JR .

HISTOCHEMISTRY, 1989, 92 (02) :133-136

[4] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES [J].

HAMILL, OP ;

MARTY, A ;

NEHER, E ;

SAKMANN, B ;

SIGWORTH, FJ .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02) :85-100

[5] INVERSE BUT NOT FULL BENZODIAZEPINE AGONISTS MODULATE RECOMBINANT ALPHA-6-BETA-2-GAMMA-2 GABA-A RECEPTORS IN TRANSFECTED HUMAN EMBRYONIC KIDNEY-CELLS [J].

KLEINGOOR, C ;

EWERT, M ;

VONBLANKENFELD, G ;

SEEBURG, PH ;

KETTENMANN, H .

NEUROSCIENCE LETTERS, 1991, 130 (02) :169-172

[6]

LITTLE HJ, 1984, BRIT J PHARMACOL, V83, P133

[7] CEREBELLAR GABA-A RECEPTOR SELECTIVE FOR A BEHAVIORAL ALCOHOL ANTAGONIST [J].

LUDDENS, H ;

PRITCHETT, DB ;

KOHLER, M ;

KILLISCH, I ;

KEINANEN, K ;

MONYER, H ;

SPRENGEL, R ;

SEEBURG, PH .

NATURE, 1990, 346 (6285) :648-651

[8] LABELING AND RECORDING FROM DISSOCIATED TARGET-SPECIFIC RAT SUPERIOR CERVICAL-GANGLION NEURONS [J].

LUEBKE, JI ;

WEIGHT, FF ;

AGUAYO, LG .

NEUROSCIENCE LETTERS, 1992, 135 (02) :210-214

[9]

MARSHALL BE, 1990, GOODMAN GILMANS PHAR, P289

[10]

MCDONALD R, 1978, NATURE, V271, P563

← 1 2 →