Size-controlled formation of a calcium phosphate-based organic-inorganic hybrid vector for gene delivery using poly(ethylene glycol)-block-poly(aspartic acid)

被引：110

作者：

Kakizawa, Y

Miyata, K

Furukawa, S

Kataoka, K

机构：

[1] Univ Tokyo, Grad Sch Engn, Dept Mat Sci & Engn, Bunkyo Ku, Tokyo 1138656, Japan

[2] Natl Inst Mat Sci, Ctr Biomat, Tsukuba, Ibaraki 3050044, Japan

来源：

ADVANCED MATERIALS | 2004年 / 16卷 / 08期

关键词：

D O I：

10.1002/adma.200305782

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Poly(ethylene glycol) (PEG)-covered hybrid particles (see Figure) of calcium phosphate (CaP), and plasmid DNA (pDNA) have been prepared in a size-controllable manner in the presence of a block copolymer. The particles show a substantial colloidal stability as well as tolerance of entrapped pDNA against nuclease attack in the medium, and achieve a significantly higher gene expression compared to conventional precipitates.

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页码：699 / +

页数：5

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