Bioresorbable Drug-Eluting Magnesium-Alloy Scaffold for Treatment of Coronary Artery Disease

被引：103

作者：

Campos, Carlos M. ^{[1
,2
]}

Muramatsu, Takashi ^{[1
,3
]}

Iqbal, Javaid ^{[1
]}

Zhang, Ya-Jun ^{[1
]}

Onuma, Yoshinobu ^{[1
]}

Garcia-Garcia, Hector M. ^{[1
]}

Haude, Michael ^{[5
]}

Lemos, Pedro A. ^{[2
]}

Warnack, Boris ^{[6
]}

Serruys, Patrick W. ^{[1
,4
]}

机构：

[1] Erasmus Univ, Med Ctr, Thoraxctr, Dept Intervent Cardiol, NL-3015 GD Rotterdam, Netherlands

[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05403000 Sao Paulo, Brazil

[3] Fujita Hlth Univ Hosp, Dept Cardiol, Tokyo 4701192, Japan

[4] Univ London Imperial Coll Sci Technol & Med, Dept Cardiol, London SW7 2AZ, England

[5] Lukaskrankenhaus GmbH, Stadt Kliniken Neuss, D-41464 Neuss, Germany

[6] BIOTRONIK AG, CH-8180 Bulach, Switzerland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 12期

关键词：

bioresorbable scaffold; drug-eluting stent; bioabsorbable; biodegradable; coronary artery disease; magnesium; INTRAVASCULAR ULTRASOUND; STENT THROMBOSIS; MULTICENTER; EXPERIENCE; IMPLANTATION; RESTENOSIS; SAFETY;

D O I：

10.3390/ijms141224492

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The introduction of metallic drug-eluting stents has reduced the risk of restenosis and widened the indications of percutaneous coronary intervention in treatment of coronary artery disease. However, this medical device can induce hypersensitive reaction that interferes with the endothelialization and healing process resulting in late persistent or acquired malapposition of the permanent metallic implant. Delayed endotheliaization and malapposition may lead to late and very late stent thrombosis. Bioresorbable scaffolds (BRS) have been introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Magnesium is an essential mineral needed for a variety of physiological functions in the human body and its bioresorbable alloy has the strength-to-weight ratio comparable with that of strong aluminum alloys and alloy steels. The aim of this review is to present the new developments in Magnesium BRS technology, to describe its clinical application and to discuss the future prospects of this innovative therapy.

引用

页码：24492 / 24500

页数：9

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