Advancing the application of omics-based biomarkers in environmental epidemiology

被引：69

作者：

Vineis, Paolo ^{[1
,2
]}

van Veldhoven, Karin ^{[1
]}

Chadeau-Hyam, Marc ^{[1
]}

Athersuch, Toby J. ^{[1
,3
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC HPA Ctr Environm & Hlth, London W2 1PG, England

[2] Human Genet Fdn, HuGeF, Mol & Genet Epidemiol Unit, Turin, Italy

[3] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Surg & Canc, London W2 1PG, England

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2013年 / 54卷 / 07期

基金：

英国医学研究理事会;

关键词：

environmental epidemiology; exposome; systems biology; compartmental models; biomarkers; BREAST-CANCER RISK; POLYCHLORINATED-BIPHENYLS; EXPOSURE RATE; DISEASE; MODELS; ESTROGEN; EXPOSOME; ALCOHOL; SMOKING; CELLS;

D O I：

10.1002/em.21764

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The use of omics represents a shift in approach for environmental epidemiology and exposure science. In this article, the aspects of the use of omics that will require further development in the near future are discussed, including (a) the underlying causal interpretation and models; (b) the meet-in-the-middle concept, with examples; (c) the role of calibration of measurements; and (d) the role of life-course epidemiology and the related development of adequate biostatistical models. (c) 2013 Wiley Periodicals, Inc.

引用

页码：461 / 467

页数：7

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