Arthropod 7SK RNA

被引：31

作者：

Gruber, Andreas R. ^{[1
]}

Kilgus, Carsten ^{[2
,7
]}

Mosig, Axel ^{[2
,3
]}

Hofacker, Ivo L. ^{[1
]}

Hennig, Wolfgang ^{[2
,7
]}

Stadler, Peter F. ^{[1
,4
,5
,6
,8
]}

机构：

[1] Univ Vienna, Inst Theoret Chem, Vienna, Austria

[2] Shanghai Inst Biol Sci, PICB, Dept Combinator & Geometry, CAS MPG, Shanghai, Peoples R China

[3] Max Planck Inst Math Sci, Leipzig, Germany

[4] Univ Leipzig, Bioinformat Grp, Dept Comp Sci, Leipzig, Germany

[5] Univ Leipzig, Interdisciplinary Ctr Bioinformat, Leipzig, Germany

[6] Fraunhofer Inst Zelltherapie & Immunol, Leipzig, Germany

[7] Johannes Gutenberg Univ Mainz, Inst Genet, Mainz, Germany

[8] Johannes Gutenberg Univ Mainz, Santa Fe Inst, Mainz, Germany

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2008年 / 25卷 / 09期

关键词：

7SK snRNA; homology search; noncoding RNA;

D O I：

10.1093/molbev/msn140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 7SK small nuclear RNA (snRNA) is a key player in the regulation of polymerase (pol) II transcription. The 7SK RNA was long believed to be specific to vertebrates where it is highly conserved. Homologs in basal deuterostomes and a few lophotrochozoan species were only recently reported. On longer timescales, 7SK evolves rapidly with only few conserved sequence and structure motifs. Previous attempts to identify the Drosophila homolog thus have remained unsuccessful despite considerable efforts. Here we report on the discovery of arthropod 7SK RNAs using a novel search strategy based on pol III promoters, as well as the subsequent verification of its expression. Our results demonstrate that a 7SK snRNA featuring 2 highly structured conserved domains was present already in the bilaterian ancestor.

引用

页码：1923 / 1930

页数：8

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