Cationic polymers and their therapeutic potential

被引：568

作者：

Samal, Sangram Keshari ^{[1
]}

Dash, Mamoni ^{[1
]}

Van Vlierberghe, Sandra ^{[1
]}

Kaplan, David L. ^{[2
]}

Chiellini, Emo ^{[3
]}

van Blitterswijk, Clemens ^{[4
]}

Moroni, Lorenzo ^{[4
]}

Dubruel, Peter ^{[1
]}

机构：

[1] Univ Ghent, Polymer Chem & Biomat Res Grp, B-9000 Ghent, Belgium

[2] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA

[3] Univ Pisa, Dept Chem & Ind Chem, Lab Bioact Polymer Mat Biomed & Environm Applicat, I-56122 San Piero A Grado, PI, Italy

[4] Univ Twente, Inst Biomed Technol & Tech Med, Tissue Regenerat Dept, NL-7500 AE Enschede, Netherlands

来源：

CHEMICAL SOCIETY REVIEWS | 2012年 / 41卷 / 21期

关键词：

POLY(BETA-AMINO ESTER) NANOPARTICLES; BIODEGRADABLE MULTIBLOCK COPOLYMERS; MOLECULAR-WEIGHT POLYETHYLENIMINE; CHITOSAN-GRAFT-POLYETHYLENIMINE; BIOREDUCIBLE POLY(AMIDO AMINE)S; GENE DELIVERY TRANSFECTION; DRUG-RELEASE BEHAVIORS; IN-VITRO; SIRNA DELIVERY; L-LYSINE;

D O I：

10.1039/c2cs35094g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and proven gene delivery efficiency. Here, we review the most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications. An overview of the synthesis and preparation of cationic polymers is provided along with their inherent bioactive and intrinsic therapeutic potential. In addition, cationic polymer based biomedical materials are covered. Major progress in the fields of drug and gene delivery as well as tissue engineering applications is summarized in the present review.

引用

页码：7147 / 7194

页数：48

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