Macrophages as APC and the Dendritic Cell Myth

被引：372

作者：

Hume, David A. ^{[1
,2
]}

机构：

[1] Roslin Inst, Roslin Bioctr, Roslin EH25 9PS, Midlothian, Scotland

[2] Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh EH8 9YL, Midlothian, Scotland

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 181卷 / 09期

关键词：

D O I：

10.4049/jimmunol.181.9.5829

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells have been considered an immune cell type that is specialized for the presentation of Ag to naive T cells. Considerable effort has been applied to separate their lineage, pathways of differentiation, and effectiveness in Ag presentation from those of macrophages. This review summarizes evidence that dendritic cells are a part of the mononuclear phagocyte system and are derived from a common precursor, responsive to the same growth factors (including CSF-1), express the same surface markers (including CD11c), and have no unique adaptation for Ag presentation that is not shared by other macrophages. The Journal of Immunology, 2008,181:5829-5835.

引用

页码：5829 / 5835

页数：7

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