Antiarrhythmic activity of 4,6-di(het)aryl-5-nitro-3,4-dihydropyrimidin-(1 H)-2-ones and its effects on arterial pressure in rats

被引：31

作者：

Bryzgalov, AO ^{[1
]}

Dolgikh, MP ^{[1
]}

Sorokina, IV ^{[1
]}

Tolstikova, TG ^{[1
]}

Sedova, VF ^{[1
]}

Shkurko, OP ^{[1
]}

机构：

[1] Russian Acad Sci, NN Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 05期

关键词：

antiarrhythmic activity; 4,6-di(het)aryl-5-nitro-3,4-dihydropyrimidin-(1H)-2-ones; arrhythmia;

D O I：

10.1016/j.bmcl.2005.11.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The antiarrhythmic activity of 4,6-di(het)aryl-5-nitro-3,4-dihydropyrimidin-(1H)-2-ones toward two types of experimental rat arrhythmia has been studied. With CaCl2 induced arrhythmia model, several agents have demonstrated high antiarrhythmic activity and the lack of influence on arterial pressure of rats. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1418 / 1420

页数：3

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