Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice

被引：108

作者：

Chen, Yan ^{[1
]}

Nie, Yi-chu ^{[1
]}

Luo, Yu-long ^{[1
]}

Lin, Feng ^{[1
]}

Zheng, Yan-fang ^{[1
]}

Cheng, Guo-hua ^{[3
]}

Wu, Hao ^{[2
]}

Zhang, Ke-jian ^{[1
]}

Su, Wei-wei ^{[1
]}

Shen, Jian-gang ^{[2
]}

Li, Pei-bo ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Key Lab Gene Engn, Guangdong Key Lab Plant Resources, Sch Life Sci,Minist Educ, Guangzhou 510275, Guangdong, Peoples R China

[2] Univ Hong Kong, Sch Chinese Med, Pokfulam, Hong Kong, Peoples R China

[3] Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 58卷

基金：

中国国家自然科学基金;

关键词：

Naringin; Acute lung injury; Pulmonary fibrosis; Anti-inflammatory; Antioxidant; Paraquat; OXIDATIVE STRESS; TISSUE INHIBITOR; CYTOTOXICITY; CELLS; ANTIOXIDANTS; EXPRESSION; QUERCETIN; INDUCTION; TOXICITY; EXTRACT;

D O I：

10.1016/j.fct.2013.04.024

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The present study evaluates protective effects of naringin against paraquat (PQ)-induced acute lung injury (ALI) and pulmonary fibrosis in mice. Survival probability against PQ intoxication was tested by a single intraperitoneal injection of PQ. Results showed that survival rates of mice exposed to PQ only (50 mg/kg within 7 days) were much lower than that in mice daily treatment with NAC or naringin. Moreover, protection against PQ-induced ALL was tested by daily pretreatment mice with saline, NAC or naringin for 3 days before PQ (30 mg/kg, i.p.). Results showed that increase in leukocytes infiltration and overexpressions of TNF-alpha and TGF-beta 1 caused by 8 h of PQ exposure were dose-dependently ameliorated by naringin. Furthermore, protection against PQ-induced pulmonary fibrosis was tested by pretreatment mice with PQ (20 mg/kg, i.p.), and then daily administration with saline, NAC or naringin for prolonged 21 days. Results showed that naringin of 60 and 120 mg/kg significantly reduced PQ-induced upregulations of TNF-alpha, TGF-beta 1, MMP-9 and TIMP-1, levels of pulmonary malonaldehyde and hydroxyproline, as well as pulmonary fibrosis deposition, while increased activities of SOD, GSH-Px and HO-1. These results indicated that naringin had effective protection against PQ-induced ALL and pulmonary fibrosis. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：133 / 140

页数：8

共 40 条

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