Performance evaluation of a hybrid linear ion trap/orbitrap mass spectrometer

被引：530

作者：

Makarov, A ^{[1
]}

Denisov, E ^{[1
]}

Kholomeev, A ^{[1
]}

Baischun, W ^{[1
]}

Lange, O ^{[1
]}

Strupat, K ^{[1
]}

Horning, S ^{[1
]}

机构：

[1] Thermo Electron Bremen GmbH, D-28199 Bremen, Germany

来源：

ANALYTICAL CHEMISTRY | 2006年 / 78卷 / 07期

关键词：

D O I：

10.1021/ac0518811

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Design and performance of a novel hybrid mass spectrometer is described. It couples a linear ion trap mass spectrometer to an orbitrap mass analyzer via an rf-only trapping quadrupole with a curved axis. The latter injects pulsed ion beams into a rapidly changing electric field in the orbitrap wherein they are trapped at high kinetic energies around an inner electrode. Image current detection is subsequently performed after a stable electrostatic field is achieved. Fourier transformation of the acquired transient allows wide mass range detection with high resolving power, mass accuracy, and dynamic range. The entire instrument operates in LC/MS mode (1 spectrum/s) with nominal mass resolving power of 60 000 and uses automatic gain control to provide high-accuracy mass measurements, within 2 ppm using internal standards and within 5 ppm with external calibration. The maximum resolving power exceeds 100 000 (fwhm). Rapid, automated data-dependent capabilities enable real-time acquisition of up to three high-mass accuracy MS/MS spectra per second.

引用

页码：2113 / 2120

页数：8

共 15 条

[1] Design and performance of an ESI interface for selective external ion accumulation coupled to a Fourier transform ion cyclotron mass spectrometer [J].