Naphthalene sulfonate polymers with CD4-blocking and anti-human immunodeficiency virus type 1 activities

被引：138

作者：

Rusconi, S

Moonis, M

Merrill, DP

Pallai, PV

Neidhardt, EA

Singh, SK

Willis, KJ

Osburne, MS

Profy, AT

Jenson, JC

Hirsch, MS

机构：

[1] MASSACHUSETTS GEN HOSP,INFECT DIS UNIT,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02114

[3] PROCEPT INC,CAMBRIDGE,MA 02139

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 01期

关键词：

D O I：

10.1128/AAC.40.1.234

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in 1-19 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.

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页码：234 / 236

页数：3

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