Quadruplex DNA crystal structures and drug design

被引：132

作者：

Neidle, Stephen ^{[1
]}

Parkinson, Gary N. ^{[1
]}

机构：

[1] Univ London, Sch Pharm, Canc Res UK Biomol Struct Grp, London WC1N 1AX, England

来源：

BIOCHIMIE | 2008年 / 90卷 / 08期

关键词：

quadruplex; crystallography; drugs;

D O I：

10.1016/j.biochi.2008.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crystallographic studies of G-quadruplex nucleic acids have resulted in a small group of structures to date. Their morphological and detailed conformational features are described here, emphasizing the stability of the G-tetrad core and the flexibility of loops, especially upon ligand binding. Implications for drug design are discussed, in the context of the druggability of both telomeric and non-telomeric quadruplex DNAs. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：1184 / 1196

页数：13

共 66 条

[1] NMR-STUDY OF PARALLEL-STRANDED TETRAPLEX FORMATION BY THE HEXADEOXYNUCLEOTIDE D(TG4T) [J].

ABOULELA, F ;

MURCHIE, AIH ;

LILLEY, DMJ .

NATURE, 1992, 360 (6401) :280-282

[2] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution [J].

Ambrus, Attila ;

Chen, Ding ;

Dai, Jixun ;

Bialis, Tiffanie ;

Jones, Roger A. ;

Yang, Danzhou .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2723-2735

[3] STRUCTURES FOR POLYINOSINIC ACID AND POLYGUANYLIC ACID [J].

ARNOTT, S ;

CHANDRASEKARAN, R ;

MARTTILA, CM .

BIOCHEMICAL JOURNAL, 1974, 141 (02) :537-+

[4] A new steroid derivative stabilizes g-quadruplexes and induces telomere uncapping in human tumor cells [J].

Brassart, Bertrand ;

Gomez, Dennis ;

De Cian, Anne ;

Paterski, Rajaa ;

Montagnac, Alain ;

Qui, Khuong-Huu ;

Temime-Smaali, Nassima ;

Trentesaux, Chantal ;

Mergny, Jean-Louis ;

Gueritte, Franc Oise ;

Riou, Jean-Francois .

MOLECULAR PHARMACOLOGY, 2007, 72 (03) :631-640

[5] Quadruplex DNA: sequence, topology and structure [J].

Burge, Sarah ;

Parkinson, Gary N. ;

Hazel, Pascale ;

Todd, Alan K. ;

Neidle, Stephen .

NUCLEIC ACIDS RESEARCH, 2006, 34 (19) :5402-5415

[6] A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions [J].

Cáceres, C ;

Wright, G ;

Gouyette, C ;

Parkinson, G ;

Subirana, JA .

NUCLEIC ACIDS RESEARCH, 2004, 32 (03) :1097-1102

[7]

Cech TR, 2000, ANGEW CHEM INT EDIT, V39, P34, DOI 10.1002/(SICI)1521-3773(20000103)39:1<34::AID-ANIE34>3.0.CO

[8]

2-N

[9] Structure of the first parallel DNA quadruplex-drug complex [J].

Clark, GR ;

Pytel, PD ;

Squire, CJ ;

Neidle, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (14) :4066-4067

[10] Structure of a d(TGGGGT) quadruplex crystallized in the presence of Li+ ions [J].

Creze, Christophe ;

Rinaldi, Bruno ;

Haser, Richard ;

Bouvet, Philippe ;

Gouet, Patrice .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2007, 63 :682-688

← 1 2 3 4 5 6 7 →