Roles of nodal-lefty regulatory loops in embryonic patterning of vertebrates

被引：63

作者：

Juan, H ^{[1
]}

Hamada, H ^{[1
]}

机构：

[1] Osaka Univ, Inst Mol & Cellular Biol, Suita, Osaka 5650871, Japan

来源：

GENES TO CELLS | 2001年 / 6卷 / 11期

关键词：

D O I：

10.1046/j.1365-2443.2001.00481.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nodal is a signalling molecule that belongs to the transforming growth factor-beta superfamily of proteins, and Lefty proteins are antagonists of Nodal signalling. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation. In this review, we will focus on recent studies that have addressed the roles of nodal and lefty in mouse development.

引用

页码：923 / 930

页数：8

共 60 条

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