Hedgehog pathway inhibition and the race against tumor evolution

被引：89

作者：

Atwood, Scott X. ^{[1
]}

Chang, Anne Lynn S. ^{[1
]}

Oro, Anthony E. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA

来源：

JOURNAL OF CELL BIOLOGY | 2012年 / 199卷 / 02期

基金：

美国国家卫生研究院;

关键词：

BASAL-CELL CARCINOMA; INTRAFLAGELLAR TRANSPORT; ACQUIRED-RESISTANCE; GLI PROTEINS; TRANSCRIPTION; MECHANISMS; CANCERS; DISEASE;

D O I：

10.1083/jcb.201207140

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dependence of basal cell carcinomas and medulloblastomas on the Hedgehog pathway provides an opportunity for targeted or "personalized" therapy. The recent effectiveness and FDA approval of the first Smoothened inhibitors validates this class of agents, but has revealed drug-resistant tumor variants that bypass Smoothened inhibition. Here, we summarize the effectiveness of Hedgehog pathway inhibitors and highlight promising areas for the development of next generation drug antagonists for Hedgehog-dependent cancers.

引用

页码：193 / 197

页数：5

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