Changes of brain gray matter structure in Parkinson's disease patients with dementia

被引：35

作者：

Xia, Jianguo ^{[1
]}

Miu, Jinlin ^{[2
]}

Ding, Hongbin ^{[1
]}

Wang, Xiuping ^{[1
]}

Chen, Hua ^{[1
]}

Wang, Juan ^{[3
]}

Wu, Juan ^{[4
]}

Zhao, Jingli ^{[4
]}

Huang, Huanxin ^{[5
]}

Tian, Weizhong ^{[1
]}

机构：

[1] Taizhou Peoples Hosp, Dept Radiol, Taizhou 225300, Jiangsu, Peoples R China

[2] Fourth Peoples Hosp Taizhou, Dept Radiol, Taizhou 225300, Jiangsu, Peoples R China

[3] Nantong Univ, Sch Med, Dept Med Image Engn, Nantong 226001, Jiangsu, Peoples R China

[4] Nantong Univ, Affiliated Hosp, Dept Radiol, Nantong 226001, Jiangsu, Peoples R China

[5] Nantong Univ, Affiliated Hosp, Dept Geriatr, Nantong 226001, Jiangsu, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 14期

关键词：

neural regeneration; neurodegenerative diseases; neuroimaging; voxel-based morphometry; Parkinson's disease; dementia; gray matter abnormality; limbic system; grants-supported paper; neuroregeneration; MILD COGNITIVE IMPAIRMENT; CORTICAL LEWY BODIES; ALZHEIMERS-DISEASE; CEREBRAL ATROPHY; FOLLOW-UP; BODY; DEFICITS; HIPPOCAMPUS; PREVALENCE; MANAGEMENT;

D O I：

10.3969/j.issn.1673-5374.2013.14.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Voxel-based morphometry is gaining considerable interest for studies examining Parkinson's disease dementia patients. In this study, 12 patients with clinically defined Parkinson's disease and dementia and 12 non-demented patients with Parkinson's disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence. Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software. Differences in gray matter volume were represented with statistical parametric mapping. Compared with Parkinson's disease patients without dementia, decreased gray matter volume in Parkinson's disease dementia patients was observed in the bilateral superior temporal gyrus, bilateral posterior cingulate and left cingulate gyrus, right parahippocampal gyrus and hippocannpus, right precuneus and tight cuneus, left inferior frontal gyrus and left insular lobe. No increased gray matter volume was apparent. These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia.

引用

页码：1276 / 1285

页数：10

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