Motor system inhibition in dopa-responsive dystonia and its modulation by treatment

被引:24
作者
Huang, YZ
Trender-Gerhard, I
Edwards, MJ
Mir, P
Rothwell, JC
Bhatia, KP
机构
[1] UCL, Neurol Inst, Sobell Dept Mol Neurosci & Movement Disorders, London WC1N 3BG, England
[2] Chang Gung Mem Hosp, Dept Neurol, Taipei, Taiwan
[3] Hosp Univ Virgen Rocio, Neurol Serv, Seville, Spain
关键词
D O I
10.1212/01.wnl.0000214304.03105.f4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Dopa-responsive dystonia (DRD) causes dystonia-parkinsonism, which is abolished by levodopa. The authors assessed short intracortical inhibition and facilitation, silent period, blink reflex recovery cycle, and reciprocal inhibition in seven patients with DRD on and off treatment. Short intracortical inhibition and blink reflex recovery cycle were reduced, but increased with treatment. Silent period was normal on and off treatment. Third phase of reciprocal inhibition was reduced on and off treatment. A discrete pattern of motor inhibitory dysfunction occurs in DRD.
引用
收藏
页码:1088 / 1090
页数:3
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