Cleavable linkers for porous silicon-based mass spectrometry

被引：43

作者：

Meng, JC

Averbuj, C

Lewis, WG

Siuzdak, G

Finn, MG

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 10期

关键词：

cleavage reactions; combinatorial chemistry; lipases; mass spectrometry; porous silicon;

D O I：

10.1002/anie.200352803

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dip, wash, and analyze: Molecules can be attached to tailored porous silicon wafers by using Diels-Alder reactions and efficiently detached and detected in the laser pulse of a MALDI mass spectrometer in a positionally encoded manner (see scheme).

引用

页码：1255 / 1260

页数：6

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