The regulation of APAF1 expression during development and tumourigenesis

被引：29

作者：

Hickman, ES ^{[1
]}

Helin, K ^{[1
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy

来源：

APOPTOSIS | 2002年 / 7卷 / 02期

关键词：

apoptosis; cancer; caspase; development; E2F; p53;

D O I：

10.1023/A:1014370616864

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis Protease-Activating Factor 1, APAF1, was originally isolated four years ago and shown to be the mammalian homologue of the C. elegans pro-apoptotic ced4 gene. Since then, the expression of APAF1 has been demonstrated to be involved in several cell death pathways, including the induction of apoptosis by the p53 tumour suppressor protein and neuronal apoptosis. In this review we will focus on the regulation of APAF1 expression, in particular with regard to recent developments in our understanding of the role of APAF1 in both tumourigenesis and mammalian development.

引用

页码：167 / 171

页数：5

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