Biodegradability of sol-gel silica microparticles for drug delivery

被引：115

作者：

Finnie, Kim S. ^{[1
]}

Waller, Daniel J. ^{[1
]}

Perret, Francois L. ^{[1
]}

Krause-Heuer, Anwen M. ^{[1
]}

Lin, Hui Q. ^{[2
]}

Hanna, John V. ^{[2
]}

Barbe, Christophe J. ^{[1
]}

机构：

[1] CeramiSphere Pty Ltd, Menai, NSW 2234, Australia

[2] Australian Nucl Sci & Technol Org, Menai, NSW 2234, Australia

来源：

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY | 2009年 / 49卷 / 01期

关键词：

Biodegradability; Encapsulation; Drug delivery; Dissolution; Microparticles; CONTROLLED-RELEASE; SIO2; MATRICES; XEROGELS; NANOPARTICLE; PARTICLES; MOLECULES; BEHAVIOR;

D O I：

10.1007/s10971-008-1847-4

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The biodegradability of porous sol-gel silica microparticles in physiological buffers has been investigated using a USP4 flow-through dissolution tester. In the open configuration, which most closely models in-vivo conditions, the particles dissolved rapidly at pH 7.4, with a rate dependent on the surface area and media flow rate. In the closed configuration, the fastest dissolving 4 mg silica sample was almost completely dissolved in 100 mL of buffer after 36 h. The initial dissolution rates appeared relatively linear but dropped off as dissolved SiO2 concentrations approached 20-25 ppm. Addition of serum proteins acted to slow dissolution by 20-30%, suggesting a slower degradation in vivo. Silica microparticles administered for controlled release drug delivery would therefore be expected to be eliminated relatively rapidly from the body, depending on the sample size and local fluid flow conditions.

引用

页码：12 / 18

页数：7

共 17 条

[1] THE SOLUBILITY OF AMORPHOUS SILICA IN WATER [J].