Structural changes and release characteristics of crosslinked chitosan beads in response to solution pH

被引：21

作者：

Gupta, KC ^{[1
]}

Kumar, MNVR ^{[1
]}

机构：

[1] Univ Roorkee, Dept Chem, Polymer Res Lab, Roorkee 247667, Uttar Pradesh, India

来源：

JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY | 1999年 / A36卷 / 5-6期

关键词：

beads; biodegradable; chitosan; controlled release; swelling degree;

D O I：

10.1081/MA-100101566

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The present investigation describes a novel method for preparing beads based on crosslinked chitosan with glutaraldehyde interpenetrating glycine polymer network. Four type of beads, viz., CHI1 (composed of chitosan, glycine and glutaraldehyde); CHI2 (composed of chitosan and glutaraldehyde); CHI3 (composed of chitosan and glycine) and CHI4 (only chitosan) were prepared and their release characteristics were studied using thyamine hydrochloride (Thy-HCl) as a model drug. Structural changes during swelling of CHI1 beads in solutions of different pH were studied using IR and UV spectroscopy.

引用

页码：827 / 841

页数：15

共 27 条

[1]

Ashford M., 1992, Journal of Pharmacy and Pharmacology, V44, P1049

[2] BIODEGRADABLE CHITOSAN MATRIX FOR THE CONTROLLED RELEASE OF STEROIDS [J].

CHANDY, T ;

SHARMA, CP .

BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY, 1991, 19 (04) :745-760

[3] CHITOSAN BEADS AND GRANULES FOR ORAL SUSTAINED DELIVERY OF NIFEDIPINE - INVITRO STUDIES [J].

CHANDY, T ;

SHARMA, CP .

BIOMATERIALS, 1992, 13 (13) :949-952

[4] CHITOSAN MATRIX FOR ORAL SUSTAINED DELIVERY OF AMPICILLIN [J].

CHANDY, T ;

SHARMA, CP .

BIOMATERIALS, 1993, 14 (12) :939-944

[5]

CHIEN YW, 1983, DRUG DEV IND PHARM, V9, P1291

[6] BIOADHESIVE POLYMERS AS PLATFORMS FOR ORAL CONTROLLED DRUG DELIVERY .2. SYNTHESIS AND EVALUATION OF SOME SWELLING, WATER-INSOLUBLE BIOADHESIVE POLYMERS [J].

CHNG, HS ;

PARK, H ;

KELLY, P ;

ROBINSON, JR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1985, 74 (04) :399-405

[7]

DEYAO K, 1993, J APPL POLYM SCI, V48, P343

[8]

DOMSZY JG, 1985, MAKROMOL CHEM, V186, P1671

[9]

HOU WM, 1985, CHEM PHARM BULL, V33, P3986

[10] ZERO-ORDER CONTROLLED-RELEASE POLYMER MATRICES FOR MICROMOLECULES AND MACROMOLECULES [J].

HSIEH, DST ;

RHINE, WD ;

LANGER, R .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (01) :17-22

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