Gastric cancer stem cells: A novel therapeutic target

被引：110

作者：

Singh, Shree Ram ^{[1
]}

机构：

[1] NCI, Mouse Canc Genet Program, Frederick, MD 21702 USA

来源：

CANCER LETTERS | 2013年 / 338卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Stomach; Gastric epithelial cells; Gastric cancer; Stem cells; Cancer stem cells; HELICOBACTER-PYLORI INFECTION; SIDE POPULATION CELLS; DRIVE SELF-RENEWAL; EPITHELIAL-CELLS; MOUSE STOMACH; PROGENITOR CELLS; PROSPECTIVE IDENTIFICATION; ATROPHIC GASTRITIS; ANTRAL EPITHELIUM; DYNAMIC HISTOLOGY;

D O I：

10.1016/j.canlet.2013.03.035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Gastric cancer remains one of the leading causes of global cancer mortality. Multipotent gastric stem cells have been identified in both mouse and human stomachs, and they play an essential role in the self-renewal and homeostasis of gastric mucosa. There are several environmental and genetic factors known to promote gastric cancer. In recent years, numerous in vitro and in vivo studies suggest that gastric cancer may originate from normal stem cells or bone marrow-derived mesenchymal cells, and that gastric tumors contain cancer stem cells. Cancer stem cells are believed to share a common microenvironment with normal niche, which play an important role in gastric cancer and tumor growth. This mini-review presents a brief overview of the recent developments in gastric cancer stem cell research. The knowledge gained by studying cancer stem cells in gastric mucosa will support the development of novel therapeutic strategies for gastric cancer. Published by Elsevier Ireland Ltd.

引用

页码：110 / 119

页数：10

共 160 条

[1]

Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells [J].

Akagi, Hideko ;

Higuchi, Hajime ;

Sumimoto, Hidetoshi ;

Igarashi, Toru ;

Kabashima, Ayano ;

Mizuguchi, Hiroyuki ;

Izumiya, Motoko ;

Sakai, Gen ;

Adachi, Masayuki ;

Funakoshi, Shinsuke ;

Nakamura, Shoko ;

Hamamoto, Yasuo ;

Kanai, Takanori ;

Takaishi, Hiromasa ;

Kawakami, Yutaka ;

Hibi, Toshifumi .

GASTRIC CANCER, 2013, 16 (01) :100-110

[2]

Expression of a candidate marker for progenitor cells, Musashi-1, in the proliferative regions of human antrum and its decreased expression in intestinal metaplasia [J].

Akasaka, Y ;

Saikawa, Y ;

Fujita, K ;

Kubota, T ;

Ishikawa, Y ;

Fujimoto, A ;

Ishii, T ;

Okano, H ;

Kitajima, M .

HISTOPATHOLOGY, 2005, 47 (04) :348-356

[3]

Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[4]

Upregulation and inhibition of the nuclear translocation of Oct4 during multistep gastric carcinogenesis [J].

Al-Marzoqee, Fathyia Y. ;

Khoder, Ghalia ;

Al-Awadhi, Haifa ;

John, Rony ;

Beg, Azam ;

Vincze, Aron ;

Branicki, Frank ;

Karam, Sherif M. .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 41 (05) :1733-1743

[5]

American Cancer Society, 2012, Cancer Facts and Figures 2012

[6]

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice [J].

Arnold, Katrin ;

Sarkar, Abby ;

Yram, Mary Anna ;

Polo, Jose M. ;

Bronson, Rod ;

Sengupta, Sumitra ;

Seandel, Marco ;

Geijsen, Niels ;

Hochedlinger, Konrad .

CELL STEM CELL, 2011, 9 (04) :317-329

[7]

Tissue-Resident Adult Stem Cell Populations of Rapidly Self-Renewing Organs [J].

Barker, Nick ;

Bartfeld, Sina ;

Clevers, Hans .

CELL STEM CELL, 2010, 7 (06) :656-670

[8]

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro [J].

Barker, Nick ;

Huch, Meritxell ;

Kujala, Pekka ;

van de Wetering, Marc ;

Snippert, Hugo J. ;

van Es, Johan H. ;

Sato, Toshiro ;

Stange, Daniel E. ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

van den Brink, Stieneke ;

Korving, Jeroen ;

Abo, Arie ;

Peters, Peter J. ;

Wright, Nick ;

Poulsom, Richard ;

Clevers, Hans .

CELL STEM CELL, 2010, 6 (01) :25-36

[9]

Multipotential stem cells in adult mouse gastric epithelium [J].

Bjerknes, M ;

Cheng, H .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 283 (03) :G767-G777

[10]

Understanding the cancer stem cell [J].

Bomken, S. ;

Fiser, K. ;

Heidenreich, O. ;

Vormoor, J. .

BRITISH JOURNAL OF CANCER, 2010, 103 (04) :439-445

← 1 2 3 4 5 6 7 8 9 10 →