Variable expression patterns of Mycobacterium tuberculosis PE-PGRS genes:: Evidence that PE-PGRS16 and PE-PGRS26 are inversely regulated in vivo

被引：56

作者：

Dheenadhayalan, Veerabadran

Delogu, Giovanni

Sanguinetti, Maurizio

Fadda, Giovanni

Brennan, Michael J.

机构：

[1] US FDA, Off Vaccines Res & Review, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

[2] Univ Sacred Heart, Inst Microbiol, Rome, Italy

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 10期

关键词：

D O I：

10.1128/JB.188.10.3721-3725.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Evaluation of expression of 16 PE-PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

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页码：3721 / 3725

页数：5

相关论文

共 25 条

[1] Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens? [J].

Banu, S ;

Honoré, N ;

Saint-Joanis, B ;

Philpott, D ;

Prévost, MC ;

Cole, ST .

MOLECULAR MICROBIOLOGY, 2002, 44 (01) :9-19

[2] Comparative genomics of BCG vaccines by whole-genome DNA microarray [J].

Behr, MA ;

Wilson, MA ;

Gill, WP ;

Salamon, H ;

Schoolnik, GK ;

Rane, S ;

Small, PM .

SCIENCE, 1999, 284 (5419) :1520-1523

[3] Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling [J].

Betts, JC ;

Lukey, PT ;

Robb, LC ;

McAdam, RA ;

Duncan, K .

MOLECULAR MICROBIOLOGY, 2002, 43 (03) :717-731

[4] Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells [J].

Brennan, MJ ;

Delogu, G ;

Chen, YP ;

Bardarov, S ;

Kriakov, J ;

Alavi, M ;

Jacobs, WR .

INFECTION AND IMMUNITY, 2001, 69 (12) :7326-7333

[5] Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [J].

Cole, ST ;

Brosch, R ;

Parkhill, J ;

Garnier, T ;

Churcher, C ;

Harris, D ;

Gordon, SV ;

Eiglmeier, K ;

Gas, S ;

Barry, CE ;

Tekaia, F ;

Badcock, K ;

Basham, D ;

Brown, D ;

Chillingworth, T ;

Connor, R ;

Davies, R ;

Devlin, K ;

Feltwell, T ;

Gentles, S ;

Hamlin, N ;

Holroyd, S ;

Hornby, T ;

Jagels, K ;

Krogh, A ;

McLean, J ;

Moule, S ;

Murphy, L ;

Oliver, K ;

Osborne, J ;

Quail, MA ;

Rajandream, MA ;

Rogers, J ;

Rutter, S ;

Seeger, K ;

Skelton, J ;

Squares, R ;

Squares, S ;

Sulston, JE ;

Taylor, K ;

Whitehead, S ;

Barrell, BG .

NATURE, 1998, 393 (6685) :537-+

[6] Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure [J].

Delogu, G ;

Pusceddu, C ;

Bua, A ;

Fadda, G ;

Brennan, MJ ;

Zanetti, S .

MOLECULAR MICROBIOLOGY, 2004, 52 (03) :725-733

[7] Comparative immune response to PE and PE_PGRS antigens of Mycobacterium tuberculosis [J].

Delogu, G ;

Brennan, MJ .

INFECTION AND IMMUNITY, 2001, 69 (09) :5606-5611

[8] Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival [J].

Dheenadhayalan, V ;

Delogu, G ;

Brennan, MJ .

MICROBES AND INFECTION, 2006, 8 (01) :262-272

[9] The PE-PGRS glycine-rich proteins of Mycobacterium tuberculosis:: a new family of fibronectin-binding proteins? [J].

Espitia, C ;

Laclette, JP ;

Mondragón-Palomino, M ;

Amador, A ;

Campuzano, J ;

Martens, A ;

Singh, M ;

Cicero, P ;

Zhang, Y ;

Moreno, C .

MICROBIOLOGY-UK, 1999, 145 :3487-3495

[10] Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes [J].

Fisher, MA ;

Plikaytis, BB ;

Shinnick, TM .

JOURNAL OF BACTERIOLOGY, 2002, 184 (14) :4025-4032